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Try also:Clinically relevant difference in the percentage of intratumoral macrophages and in the expression of chemokines and cytokines by human macrophages cocultivated with oral squamous cell carcinoma cells.
Tumor-associated macrophages (TAMs) play an important role in tumor progression and metastasis. Macrophages can be divided into a classically activated M1 subtype, which promotes cell-mediated immunity, and an alternatively activated M2 subtype, which favors a Th2 type response. We have previously shown in vitro that oral cancer cells can induce TAM polarization, indicating that they are important in the recruitment and modulation of TAMs. However, little is known about the composition of TAMs and the TAM polarization status in vivo. In the present study, we examined the expression of M1 and M2-related markers in TAMs in human oral squamous cell carcinoma (OSCC) and in cocultures with OSCC cell lines. Macrophages were isolated from endoscopic biopsy tissue samples of OSCC patients. In the coculture studies, we used OSCC cell lines such as SNU1041, SNU899 and HSC-3, and the macrophage cell line, U937. Immunohistochemistry and real-time PCR analyses showed that M1 macrophages were mainly recruited to the tumor stroma of OSCCs, while M2 macrophages were recruited to the tumor stroma and to the tumor cell clusters. M1 and M2 polarization markers were also detected. The number of M2 macrophages increased as the tumor cells became more aggressive. In OSCC, the expression of CCL17 and CX
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